Drug interactions
Liposomal doxorubicin + Sorafenib
Severity: Moderate
Liposomal doxorubicin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib has been associated with variable increases in doxorubicin exposure in small studies. The clinical impact is unclear, but both drugs can contribute to cardiac and hematologic toxicity.
What this interaction means in plain words
Liposomal doxorubicin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
The mechanism is not established; possible inhibition of transporters or metabolism by sorafenib.
What to do
Monitor blood counts, blood pressure, and cardiac function (LVEF) during combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Liposomal doxorubicin with Sorafenib?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib has been associated with variable increases in doxorubicin exposure in small studies. The clinical impact is unclear, but both drugs can contribute to cardiac and hematologic toxicity.
How serious is the interaction between Liposomal doxorubicin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, blood pressure, and cardiac function (LVEF) during combined therapy.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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