Drug interactions
Liposomal doxorubicin + Stavudine
Severity: Moderate
Liposomal doxorubicin and Stavudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin may reduce the antiviral activity of stavudine by interfering with its intracellular activation. This could reduce HIV suppression.
What this interaction means in plain words
Liposomal doxorubicin and Stavudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liposomal doxorubicin belongs to Oncology; Stavudine belongs to Anti Virals.
Why it happens
Doxorubicin impairs intracellular phosphorylation of stavudine to its active triphosphate.
What to do
Monitor HIV viral load during chemotherapy, and consider an antiretroviral regimen without stavudine, which is rarely used now.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Stavudine
- Didanosine + Stavudine Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Stavudine Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Stavudine Major
- Betibeglogene autotemcel + Stavudine Major
Frequently asked questions
Can I take Liposomal doxorubicin with Stavudine?
MediHelp rates the interaction as moderate. Liposomal doxorubicin and Stavudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxorubicin may reduce the antiviral activity of stavudine by interfering with its intracellular activation. This could reduce HIV suppression.
How serious is the interaction between Liposomal doxorubicin and Stavudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load during chemotherapy, and consider an antiretroviral regimen without stavudine, which is rarely used now.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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