Drug interactions
Liraglutide + Lisinopril
Severity: Minor
Liraglutide and Lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may modestly increase the glucose-lowering effect of antidiabetic agents, and this could add to liraglutide's effect. The risk of hypoglycemia is low with liraglutide alone but rises if other glucose-lowering drugs are also used.
What this interaction means in plain words
Liraglutide and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liraglutide belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
Not clearly established; ACE inhibition may improve insulin sensitivity, adding to the glucose-lowering effect of liraglutide.
What to do
Monitor glycemic control when starting lisinopril, especially if insulin or a sulfonylurea is also taken. Reduce the dose of those agents if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Lisinopril?
MediHelp rates the interaction as minor. Liraglutide and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may modestly increase the glucose-lowering effect of antidiabetic agents, and this could add to liraglutide's effect. The risk of hypoglycemia is low with liraglutide alone but rises if other glucose-lowering drugs are also used.
How serious is the interaction between Liraglutide and Lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when starting lisinopril, especially if insulin or a sulfonylurea is also taken. Reduce the dose of those agents if hypoglycemia occurs.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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