Drug interactions
Liraglutide + Metformin-repaglinide
Severity: Moderate
Liraglutide and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide enhances glucose-dependent insulin secretion and, combined with repaglinide, raises the risk of hypoglycemia. Metformin alone adds little hypoglycemia risk but contributes to overall glucose lowering.
What this interaction means in plain words
Liraglutide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive insulinotropic effects of GLP-1 receptor agonism and repaglinide-induced insulin secretion.
What to do
Monitor blood glucose and consider reducing the repaglinide dose when starting liraglutide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Liraglutide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide enhances glucose-dependent insulin secretion and, combined with repaglinide, raises the risk of hypoglycemia. Metformin alone adds little hypoglycemia risk but contributes to overall glucose lowering.
How serious is the interaction between Liraglutide and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider reducing the repaglinide dose when starting liraglutide.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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