Drug interactions
Liraglutide + Nateglinide
Severity: Moderate
Liraglutide and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide enhances glucose-dependent insulin secretion, and nateglinide stimulates insulin release as well. Combined use can increase the risk of hypoglycemia, as seen with other insulin secretagogue combinations with GLP-1 agonists.
What this interaction means in plain words
Liraglutide and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects through insulin secretion.
What to do
Monitor blood glucose when liraglutide is started or the dose is changed, and reduce the nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Nateglinide?
MediHelp rates the interaction as moderate. Liraglutide and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide enhances glucose-dependent insulin secretion, and nateglinide stimulates insulin release as well. Combined use can increase the risk of hypoglycemia, as seen with other insulin secretagogue combinations with GLP-1 agonists.
How serious is the interaction between Liraglutide and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when liraglutide is started or the dose is changed, and reduce the nateglinide dose if hypoglycemia occurs.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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