Drug interactions
Liraglutide + Prednisolone
Severity: Moderate
Liraglutide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids raise blood glucose and can counteract the glucose-lowering action of liraglutide. Glycemic control may worsen, particularly with higher steroid doses.
What this interaction means in plain words
Liraglutide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Liraglutide belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: corticosteroids promote insulin resistance and hepatic gluconeogenesis, opposing GLP-1 receptor agonist effects.
What to do
Monitor blood glucose more frequently when starting, changing or stopping prednisolone, and adjust antidiabetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Prednisolone?
MediHelp rates the interaction as moderate. Liraglutide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids raise blood glucose and can counteract the glucose-lowering action of liraglutide. Glycemic control may worsen, particularly with higher steroid doses.
How serious is the interaction between Liraglutide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, changing or stopping prednisolone, and adjust antidiabetic therapy accordingly.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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