Drug interactions
Liraglutide + Sacubitril-valsartan
Severity: Minor
Liraglutide and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockade may modestly improve insulin sensitivity, which could add to the glucose-lowering effect of liraglutide. The clinical impact is usually small, and hypoglycemia is unlikely without other agents such as insulin or sulfonylureas.
What this interaction means in plain words
Liraglutide and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Liraglutide belongs to Endocrine; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Possible additive glucose lowering through improved insulin sensitivity with RAAS blockade.
What to do
Monitor glycemic control when starting or changing sacubitril-valsartan. Adjust antidiabetic therapy only if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Liraglutide
Frequently asked questions
Can I take Liraglutide with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Liraglutide and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockade may modestly improve insulin sensitivity, which could add to the glucose-lowering effect of liraglutide. The clinical impact is usually small, and hypoglycemia is unlikely without other agents such as insulin or sulfonylureas.
How serious is the interaction between Liraglutide and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control when starting or changing sacubitril-valsartan. Adjust antidiabetic therapy only if glucose falls.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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