Drug interactions
Lisinopril + Lurasidone
Severity: Moderate
Lisinopril and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone blocks alpha-1 adrenergic receptors and can lower blood pressure, particularly when starting treatment or increasing the dose. Combined with lisinopril, this can add to the blood pressure reduction and cause dizziness, orthostatic hypotension or syncope.
What this interaction means in plain words
Lisinopril and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotensive effect from alpha-1 adrenergic antagonism by lurasidone and ACE inhibition by lisinopril.
What to do
Monitor blood pressure and orthostatic symptoms when lurasidone is started or titrated. Reduce the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lisinopril with Lurasidone?
MediHelp rates the interaction as moderate. Lisinopril and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone blocks alpha-1 adrenergic receptors and can lower blood pressure, particularly when starting treatment or increasing the dose. Combined with lisinopril, this can add to the blood pressure reduction and cause dizziness, orthostatic hypotension or syncope.
How serious is the interaction between Lisinopril and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when lurasidone is started or titrated. Reduce the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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