Drug interactions
Lisinopril + Perphenazine
Severity: Minor
Lisinopril and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has modest alpha-blocking activity that may produce orthostatic hypotension. This can add to the blood pressure lowering effect of lisinopril.
What this interaction means in plain words
Lisinopril and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lisinopril belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-1 adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or changing doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Lisinopril with Perphenazine?
MediHelp rates the interaction as minor. Lisinopril and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine has modest alpha-blocking activity that may produce orthostatic hypotension. This can add to the blood pressure lowering effect of lisinopril.
How serious is the interaction between Lisinopril and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or changing doses.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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