Drug interactions
Lisinopril + Potassium iodide
Severity: Moderate
Lisinopril and Potassium iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide delivers a potassium load, and lisinopril reduces renal potassium elimination. Hyperkalemia is possible, mainly with long-term or high-dose iodide use or impaired kidney function.
What this interaction means in plain words
Lisinopril and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Potassium iodide belongs to Endocrine.
Why it happens
ACE inhibition reduces aldosterone-dependent potassium excretion while the iodide salt adds potassium.
What to do
Monitor serum potassium with prolonged or repeated potassium iodide dosing; short single-course use for thyroid blockade rarely needs action.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Lisinopril with Potassium iodide?
MediHelp rates the interaction as moderate. Lisinopril and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide delivers a potassium load, and lisinopril reduces renal potassium elimination. Hyperkalemia is possible, mainly with long-term or high-dose iodide use or impaired kidney function.
How serious is the interaction between Lisinopril and Potassium iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium with prolonged or repeated potassium iodide dosing; short single-course use for thyroid blockade rarely needs action.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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