Drug interactions
Lisinopril + Sirolimus
Severity: Major
Lisinopril and Sirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus combined with an ACE inhibitor increases the risk of angioedema, which can involve the face, lips, tongue or airway. Reactions may occur at any time during therapy and can be life-threatening.
What this interaction means in plain words
Lisinopril and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lisinopril belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
Both drugs impair bradykinin breakdown (ACE inhibition and mTOR inhibitor effect on dipeptidyl peptidase IV), so bradykinin accumulates.
What to do
Counsel patients to seek urgent care for swelling of the face, lips, tongue or throat. Stop the ACE inhibitor and use an alternative antihypertensive if angioedema occurs, or avoid the combination in patients with prior angioedema.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Lisinopril with Sirolimus?
MediHelp rates the interaction as major. Lisinopril and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sirolimus combined with an ACE inhibitor increases the risk of angioedema, which can involve the face, lips, tongue or airway. Reactions may occur at any time during therapy and can be life-threatening.
How serious is the interaction between Lisinopril and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to seek urgent care for swelling of the face, lips, tongue or throat. Stop the ACE inhibitor and use an alternative antihypertensive if angioedema occurs, or avoid the combination in patients with prior angioedema.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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