Drug interactions
Lisinopril + Torsemide
Severity: Moderate
Lisinopril and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding lisinopril to a loop diuretic can cause marked hypotension, especially after the first dose or with volume depletion. Renal function may also decline.
What this interaction means in plain words
Lisinopril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lisinopril belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Diuretic-induced renin-angiotensin activation is blocked by ACE inhibition, giving additive hypotension and reduced glomerular filtration.
What to do
Monitor blood pressure, creatinine and potassium after starting or titrating, and consider lowering the diuretic dose before initiating lisinopril in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Lisinopril with Torsemide?
MediHelp rates the interaction as moderate. Lisinopril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding lisinopril to a loop diuretic can cause marked hypotension, especially after the first dose or with volume depletion. Renal function may also decline.
How serious is the interaction between Lisinopril and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting or titrating, and consider lowering the diuretic dose before initiating lisinopril in volume-depleted patients.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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