Drug interactions
Lithium + Midostaurin
Severity: Moderate
Lithium and Midostaurin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte disturbance or heart disease.
What this interaction means in plain words
Lithium and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Midostaurin belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Obtain a baseline ECG and monitor it periodically, and keep potassium and magnesium in the normal range. Consider alternatives if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Midostaurin
Frequently asked questions
Can I take Lithium with Midostaurin?
MediHelp rates the interaction as moderate. Lithium and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte disturbance or heart disease.
How serious is the interaction between Lithium and Midostaurin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and keep potassium and magnesium in the normal range. Consider alternatives if QTc becomes markedly prolonged.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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