Drug interactions
Lithium + Ozanimod
Severity: Moderate
Lithium and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod may cause heart rate slowing and QT effects, and lithium can also affect cardiac conduction and repolarization. The labeled MAO-B concern is related to serotonergic and noradrenergic drugs, and its relevance to lithium is uncertain.
What this interaction means in plain words
Lithium and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Possible additive effects on cardiac conduction and repolarization; the MAO-B inhibition concern is theoretical for lithium.
What to do
Check a baseline ECG and monitor heart rate and blood pressure after starting ozanimod. Use particular care in patients with bradycardia, conduction disease or QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Lithium with Ozanimod?
MediHelp rates the interaction as moderate. Lithium and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod may cause heart rate slowing and QT effects, and lithium can also affect cardiac conduction and repolarization. The labeled MAO-B concern is related to serotonergic and noradrenergic drugs, and its relevance to lithium is uncertain.
How serious is the interaction between Lithium and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor heart rate and blood pressure after starting ozanimod. Use particular care in patients with bradycardia, conduction disease or QT risk factors.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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