Drug interactions
Lithium + Ranolazine
Severity: Moderate
Lithium and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium can cause QT prolongation and T-wave changes, especially at higher levels, and ranolazine also lengthens the QT interval. Combined use may increase the risk of arrhythmia.
What this interaction means in plain words
Lithium and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Additive effects on cardiac repolarization causing QT prolongation.
What to do
Monitor the ECG and serum lithium concentration, keeping lithium within the therapeutic range. Correct electrolyte abnormalities and avoid dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Ranolazine?
MediHelp rates the interaction as moderate. Lithium and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lithium can cause QT prolongation and T-wave changes, especially at higher levels, and ranolazine also lengthens the QT interval. Combined use may increase the risk of arrhythmia.
How serious is the interaction between Lithium and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG and serum lithium concentration, keeping lithium within the therapeutic range. Correct electrolyte abnormalities and avoid dehydration.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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