Drug interactions
Lithium + Triclabendazole
Severity: Moderate
Lithium and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole can prolong the QT interval, and lithium may add to this effect. The combined risk of arrhythmia is likely small but higher with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Lithium and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check an ECG beforehand if the patient has other QT risk factors and correct hypokalemia and hypomagnesemia. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Lithium with Triclabendazole?
MediHelp rates the interaction as moderate. Lithium and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole can prolong the QT interval, and lithium may add to this effect. The combined risk of arrhythmia is likely small but higher with electrolyte disturbance or cardiac disease.
How serious is the interaction between Lithium and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG beforehand if the patient has other QT risk factors and correct hypokalemia and hypomagnesemia. Monitor for palpitations or syncope.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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