Drug interactions
Lithium + Trimipramine
Severity: Moderate
Lithium and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining lithium with a tricyclic antidepressant can increase the risk of serotonergic effects, tremor and neurotoxicity, and both drugs may affect cardiac conduction and the QT interval. The combination is used clinically for augmentation but needs careful oversight.
What this interaction means in plain words
Lithium and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lithium belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive serotonergic, neurotoxic and QT-prolonging pharmacodynamic effects.
What to do
Monitor serum lithium levels, renal function and electrolytes, and obtain an ECG at baseline. Watch for tremor, confusion, myoclonus and signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Lithium with Trimipramine?
MediHelp rates the interaction as moderate. Lithium and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining lithium with a tricyclic antidepressant can increase the risk of serotonergic effects, tremor and neurotoxicity, and both drugs may affect cardiac conduction and the QT interval. The combination is used clinically for augmentation but needs careful oversight.
How serious is the interaction between Lithium and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum lithium levels, renal function and electrolytes, and obtain an ECG at baseline. Watch for tremor, confusion, myoclonus and signs of serotonin toxicity.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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