Drug interactions
Lofepramine + Midodrine
Severity: Moderate
Lofepramine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic, inhibits norepinephrine reuptake and may change responses to vasopressors. With midodrine this may cause excessive blood pressure elevation.
What this interaction means in plain words
Lofepramine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of norepinephrine reuptake modifies adrenergic response to midodrine.
What to do
Monitor blood pressure and heart rate, including supine readings. Reduce midodrine dose if hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Lofepramine with Midodrine?
MediHelp rates the interaction as moderate. Lofepramine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine, a tricyclic, inhibits norepinephrine reuptake and may change responses to vasopressors. With midodrine this may cause excessive blood pressure elevation.
How serious is the interaction between Lofepramine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, including supine readings. Reduce midodrine dose if hypertension occurs.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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