Drug interactions
Lofepramine + Mirtazapine
Severity: Moderate
Lofepramine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a tricyclic antidepressant with mirtazapine increases sedation and may add to serotonergic and anticholinergic effects. Lofepramine is a prodrug of desipramine, and duplicated antidepressant therapy raises the risk of adverse effects including serotonin toxicity, though this is uncommon.
What this interaction means in plain words
Lofepramine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedative and serotonergic/noradrenergic pharmacodynamic effects.
What to do
Avoid routine combination; if used, start at low doses and monitor for sedation, serotonin toxicity, cardiac effects and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Lofepramine with Mirtazapine?
MediHelp rates the interaction as moderate. Lofepramine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a tricyclic antidepressant with mirtazapine increases sedation and may add to serotonergic and anticholinergic effects. Lofepramine is a prodrug of desipramine, and duplicated antidepressant therapy raises the risk of adverse effects including serotonin toxicity, though this is uncommon.
How serious is the interaction between Lofepramine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if used, start at low doses and monitor for sedation, serotonin toxicity, cardiac effects and blood pressure.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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