Drug interactions
Lofepramine + Modafinil
Severity: Moderate
Lofepramine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with sedative potential, whereas modafinil promotes wakefulness. Modafinil may inhibit CYP2C19 and raise some tricyclic levels, and both may affect heart rate.
What this interaction means in plain words
Lofepramine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS effects and possible CYP2C19/CYP2D6-related changes in tricyclic metabolism.
What to do
Monitor for tricyclic adverse effects such as anticholinergic symptoms, tachycardia and arrhythmia, and adjust the lofepramine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Frequently asked questions
Can I take Lofepramine with Modafinil?
MediHelp rates the interaction as moderate. Lofepramine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with sedative potential, whereas modafinil promotes wakefulness. Modafinil may inhibit CYP2C19 and raise some tricyclic levels, and both may affect heart rate.
How serious is the interaction between Lofepramine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects such as anticholinergic symptoms, tachycardia and arrhythmia, and adjust the lofepramine dose if needed.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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