Drug interactions
Lofepramine + Tiotropium-olodaterol
Severity: Moderate
Lofepramine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with anticholinergic properties and can add to tiotropium's antimuscarinic effects. Dry mouth, constipation, urinary retention and tachycardia may increase.
What this interaction means in plain words
Lofepramine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic effects, particularly in older adults. Reduce the burden of other anticholinergic drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Lofepramine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Lofepramine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with anticholinergic properties and can add to tiotropium's antimuscarinic effects. Dry mouth, constipation, urinary retention and tachycardia may increase.
How serious is the interaction between Lofepramine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly in older adults. Reduce the burden of other anticholinergic drugs where possible.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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