Drug interactions
Lofexidine + Losartan
Severity: Moderate
Lofexidine and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and lofexidine also slows heart rate. Together they can cause excessive hypotension, dizziness, syncope and bradycardia.
What this interaction means in plain words
Lofexidine and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Losartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering from angiotensin receptor blockade and central alpha-2 agonism, plus lofexidine bradycardia.
What to do
Monitor blood pressure and heart rate, especially when starting or adjusting doses. Reduce the dose of one agent if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Losartan?
MediHelp rates the interaction as moderate. Lofexidine and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and lofexidine also slows heart rate. Together they can cause excessive hypotension, dizziness, syncope and bradycardia.
How serious is the interaction between Lofexidine and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially when starting or adjusting doses. Reduce the dose of one agent if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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