Drug interactions
Lofexidine + Metoprolol
Severity: Moderate
Lofexidine and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine is a central alpha-2 agonist that lowers heart rate and blood pressure, and metoprolol has similar effects through beta-blockade. Used together they can produce marked bradycardia, hypotension and syncope. Lofexidine also prolongs the QT interval, which adds to the concern in susceptible patients.
What this interaction means in plain words
Lofexidine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Metoprolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic reduction of heart rate and blood pressure through central sympatholytic and beta-adrenergic blocking actions.
What to do
Monitor heart rate and blood pressure closely, especially during lofexidine initiation and dose titration, and reduce or hold doses for symptomatic bradycardia or hypotension. Consider an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Metoprolol?
MediHelp rates the interaction as moderate. Lofexidine and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine is a central alpha-2 agonist that lowers heart rate and blood pressure, and metoprolol has similar effects through beta-blockade. Used together they can produce marked bradycardia, hypotension and syncope. Lofexidine also prolongs the QT interval, which adds to the concern in susceptible patients.
How serious is the interaction between Lofexidine and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure closely, especially during lofexidine initiation and dose titration, and reduce or hold doses for symptomatic bradycardia or hypotension. Consider an ECG in patients with other QT risk factors.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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