Drug interactions
Lofexidine + Mirabegron
Severity: Moderate
Lofexidine and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron is a moderate inhibitor of CYP2D6, which is a major route of lofexidine clearance. Higher lofexidine exposure could increase hypotension, orthostasis and bradycardia.
What this interaction means in plain words
Lofexidine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, reducing the metabolism of lofexidine.
What to do
Monitor blood pressure and heart rate, particularly on starting or stopping mirabegron. Reduce the lofexidine dose if orthostasis or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Mirabegron?
MediHelp rates the interaction as moderate. Lofexidine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirabegron is a moderate inhibitor of CYP2D6, which is a major route of lofexidine clearance. Higher lofexidine exposure could increase hypotension, orthostasis and bradycardia.
How serious is the interaction between Lofexidine and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly on starting or stopping mirabegron. Reduce the lofexidine dose if orthostasis or bradycardia develops.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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