Drug interactions
Lofexidine + Oxaliplatin
Severity: Moderate
Lofexidine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine can prolong the QT interval and cause bradycardia and hypotension, and oxaliplatin may add to QT effects. Combined use may raise the risk of arrhythmia.
What this interaction means in plain words
Lofexidine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Oxaliplatin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation, with lofexidine bradycardia adding to proarrhythmic risk.
What to do
Monitor ECG, heart rate and blood pressure, and correct electrolyte abnormalities. Avoid the combination in patients with baseline QT prolongation or bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Lofexidine with Oxaliplatin?
MediHelp rates the interaction as moderate. Lofexidine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine can prolong the QT interval and cause bradycardia and hypotension, and oxaliplatin may add to QT effects. Combined use may raise the risk of arrhythmia.
How serious is the interaction between Lofexidine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and blood pressure, and correct electrolyte abnormalities. Avoid the combination in patients with baseline QT prolongation or bradycardia.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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