Drug interactions
Lofexidine + Temazepam
Severity: Moderate
Lofexidine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine and temazepam both cause drowsiness and psychomotor impairment. Together they may produce excessive sedation, dizziness and a greater risk of falls, particularly in older patients.
What this interaction means in plain words
Lofexidine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lofexidine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of an alpha-2 agonist and a benzodiazepine.
What to do
Monitor for oversedation and hypotension, and use the lowest effective temazepam dose. Advise patients against driving or operating machinery until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Lofexidine with Temazepam?
MediHelp rates the interaction as moderate. Lofexidine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine and temazepam both cause drowsiness and psychomotor impairment. Together they may produce excessive sedation, dizziness and a greater risk of falls, particularly in older patients.
How serious is the interaction between Lofexidine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and hypotension, and use the lowest effective temazepam dose. Advise patients against driving or operating machinery until the response is known.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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