Drug interactions
Lomitapide + Lorlatinib
Severity: Moderate
Lomitapide and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a CYP3A4 substrate, so lorlatinib may reduce its exposure and lipid-lowering effect. Lipid control could worsen.
What this interaction means in plain words
Lomitapide and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing lomitapide clearance.
What to do
Monitor LDL cholesterol and adjust the lomitapide dose per response. Note that lorlatinib itself raises lipids, so follow lipid panels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Lorlatinib?
MediHelp rates the interaction as moderate. Lomitapide and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a CYP3A4 substrate, so lorlatinib may reduce its exposure and lipid-lowering effect. Lipid control could worsen.
How serious is the interaction between Lomitapide and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LDL cholesterol and adjust the lomitapide dose per response. Note that lorlatinib itself raises lipids, so follow lipid panels.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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