Drug interactions
Lomitapide + Methadone
Severity: Minor
Lomitapide and Methadone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone is not a recognized inhibitor of CYP3A4 that would meaningfully raise lomitapide exposure. Any interaction is therefore not established, and the legacy direction of effect cannot be confirmed.
What this interaction means in plain words
Lomitapide and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lomitapide belongs to Cardiovascular; Methadone belongs to Musculoskeletal.
Why it happens
No established mechanism; lomitapide is a CYP3A4 substrate but methadone is not a clinically relevant CYP3A4 inhibitor.
What to do
No dose adjustment is needed. Monitor liver enzymes as part of routine lomitapide therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Methadone?
MediHelp rates the interaction as minor. Lomitapide and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methadone is not a recognized inhibitor of CYP3A4 that would meaningfully raise lomitapide exposure. Any interaction is therefore not established, and the legacy direction of effect cannot be confirmed.
How serious is the interaction between Lomitapide and Methadone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor liver enzymes as part of routine lomitapide therapy.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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