Drug interactions
Lomitapide + Nilotinib
Severity: Major
Lomitapide and Nilotinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib is a CYP3A4 inhibitor and may raise lomitapide exposure, increasing the risk of hepatotoxicity and gastrointestinal adverse effects. Lomitapide is highly dependent on CYP3A4 for clearance, so even weak to moderate inhibition matters.
What this interaction means in plain words
Lomitapide and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lomitapide belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lomitapide by nilotinib.
What to do
Limit the lomitapide dose to the labeled maximum for use with weak or moderate CYP3A4 inhibitors (30 mg/day). Monitor liver enzymes and tolerability closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Nilotinib?
MediHelp rates the interaction as major. Lomitapide and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nilotinib is a CYP3A4 inhibitor and may raise lomitapide exposure, increasing the risk of hepatotoxicity and gastrointestinal adverse effects. Lomitapide is highly dependent on CYP3A4 for clearance, so even weak to moderate inhibition matters.
How serious is the interaction between Lomitapide and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lomitapide dose to the labeled maximum for use with weak or moderate CYP3A4 inhibitors (30 mg/day). Monitor liver enzymes and tolerability closely.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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