Drug interactions
Lomitapide + Oxybutynin
Severity: Moderate
Lomitapide and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin is a weak CYP3A4 inhibitor and may increase lomitapide exposure, raising the risk of hepatotoxicity and gastrointestinal adverse effects. Lomitapide labeling limits its dose when weak CYP3A4 inhibitors are used.
What this interaction means in plain words
Lomitapide and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Oxybutynin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lomitapide.
What to do
Limit the lomitapide dose according to labeling when given with weak CYP3A4 inhibitors and monitor liver enzymes closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Oxybutynin?
MediHelp rates the interaction as moderate. Lomitapide and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybutynin is a weak CYP3A4 inhibitor and may increase lomitapide exposure, raising the risk of hepatotoxicity and gastrointestinal adverse effects. Lomitapide labeling limits its dose when weak CYP3A4 inhibitors are used.
How serious is the interaction between Lomitapide and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lomitapide dose according to labeling when given with weak CYP3A4 inhibitors and monitor liver enzymes closely.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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