Drug interactions
Lomitapide + Pazopanib
Severity: Major
Lomitapide and Pazopanib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib may inhibit CYP3A4 weakly and raise lomitapide exposure, increasing hepatotoxicity and gastrointestinal effects. Both drugs are hepatotoxic, so combined liver injury risk is increased.
What this interaction means in plain words
Lomitapide and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lomitapide belongs to Cardiovascular; Pazopanib belongs to Oncology.
Why it happens
CYP3A4 inhibition may increase lomitapide exposure, with additive hepatotoxicity.
What to do
Avoid if possible; otherwise monitor liver enzymes frequently and limit lomitapide dose per labeling for CYP3A4 inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Pazopanib?
MediHelp rates the interaction as major. Lomitapide and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib may inhibit CYP3A4 weakly and raise lomitapide exposure, increasing hepatotoxicity and gastrointestinal effects. Both drugs are hepatotoxic, so combined liver injury risk is increased.
How serious is the interaction between Lomitapide and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor liver enzymes frequently and limit lomitapide dose per labeling for CYP3A4 inhibitors.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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