Drug interactions
Lomitapide + Quinine
Severity: Moderate
Lomitapide and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a CYP3A4 substrate, and weak CYP3A4 inhibitors raise its exposure. Quinine inhibits CYP3A4 modestly, so lomitapide levels may increase, worsening hepatotoxicity and gastrointestinal effects.
What this interaction means in plain words
Lomitapide and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Quinine inhibits CYP3A4, decreasing the first-pass and systemic metabolism of lomitapide.
What to do
Limit lomitapide to the labeled maximum for weak CYP3A4 inhibitors and monitor liver enzymes and GI tolerance. Avoid prolonged coadministration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Quinine?
MediHelp rates the interaction as moderate. Lomitapide and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a CYP3A4 substrate, and weak CYP3A4 inhibitors raise its exposure. Quinine inhibits CYP3A4 modestly, so lomitapide levels may increase, worsening hepatotoxicity and gastrointestinal effects.
How serious is the interaction between Lomitapide and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lomitapide to the labeled maximum for weak CYP3A4 inhibitors and monitor liver enzymes and GI tolerance. Avoid prolonged coadministration.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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