Drug interactions
Lomitapide + Tamoxifen
Severity: Moderate
Lomitapide and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamoxifen can inhibit CYP3A4 weakly, potentially increasing lomitapide exposure. Both drugs can raise liver enzymes and cause hepatic steatosis, so hepatotoxicity risk is additive.
What this interaction means in plain words
Lomitapide and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Tamoxifen belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition plus additive hepatotoxicity.
What to do
Limit lomitapide to the labeled maximum dose with weak CYP3A4 inhibitors and monitor ALT and AST regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Tamoxifen?
MediHelp rates the interaction as moderate. Lomitapide and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tamoxifen can inhibit CYP3A4 weakly, potentially increasing lomitapide exposure. Both drugs can raise liver enzymes and cause hepatic steatosis, so hepatotoxicity risk is additive.
How serious is the interaction between Lomitapide and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lomitapide to the labeled maximum dose with weak CYP3A4 inhibitors and monitor ALT and AST regularly.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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