Drug interactions
Lomitapide + Tetracycline
Severity: Moderate
Lomitapide and Tetracycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is mainly cleared by CYP3A4, and drugs that inhibit this enzyme markedly raise its exposure. This increases the risk of hepatotoxicity and gastrointestinal adverse effects. Tetracycline itself is not a recognized strong CYP3A4 inhibitor, so the size of this effect is uncertain.
What this interaction means in plain words
Lomitapide and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Tetracycline belongs to Anti Bacterial.
Why it happens
Possible weak inhibition of CYP3A4-mediated lomitapide metabolism; the mechanism is not well established for tetracycline.
What to do
Monitor liver enzymes and gastrointestinal tolerability when tetracycline is given with lomitapide, and reduce the lomitapide dose if transaminases rise. Prefer an antibiotic without CYP3A4 effects if a short course is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Tetracycline?
MediHelp rates the interaction as moderate. Lomitapide and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is mainly cleared by CYP3A4, and drugs that inhibit this enzyme markedly raise its exposure. This increases the risk of hepatotoxicity and gastrointestinal adverse effects. Tetracycline itself is not a recognized strong CYP3A4 inhibitor, so the size of this effect is uncertain.
How serious is the interaction between Lomitapide and Tetracycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and gastrointestinal tolerability when tetracycline is given with lomitapide, and reduce the lomitapide dose if transaminases rise. Prefer an antibiotic without CYP3A4 effects if a short course is needed.
What other medicines interact with Tetracycline?
MediHelp also lists interactions of Tetracycline with, for example, Acitretin, Methoxyflurane, Isotretinoin. The full list is on the Tetracycline page.
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