Drug interactions
Lomitapide + Vincristine
Severity: Moderate
Lomitapide and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-gp and may increase vincristine exposure, raising the risk of neurotoxicity. Vincristine is not a meaningful CYP3A4 inhibitor, so the effect on lomitapide is unlikely to matter. Lomitapide also carries hepatotoxicity concerns that add to the overall burden.
What this interaction means in plain words
Lomitapide and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lomitapide belongs to Cardiovascular; Vincristine belongs to Oncology.
Why it happens
Lomitapide inhibits P-gp efflux, potentially increasing vincristine concentrations.
What to do
Monitor for neuropathy, constipation and liver enzyme elevations. Consider reducing the vincristine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Lomitapide with Vincristine?
MediHelp rates the interaction as moderate. Lomitapide and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide inhibits P-gp and may increase vincristine exposure, raising the risk of neurotoxicity. Vincristine is not a meaningful CYP3A4 inhibitor, so the effect on lomitapide is unlikely to matter. Lomitapide also carries hepatotoxicity concerns that add to the overall burden.
How serious is the interaction between Lomitapide and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, constipation and liver enzyme elevations. Consider reducing the vincristine dose if toxicity develops.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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