Drug interactions
Lonafarnib + Methadone
Severity: Moderate
Lonafarnib and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and methadone is a weak CYP3A inhibitor that may modestly raise lonafarnib exposure. The effect of lonafarnib on QT is not fully defined, so increased exposure with a QT-prolonging drug is a concern.
What this interaction means in plain words
Lonafarnib and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Methadone belongs to Musculoskeletal.
Why it happens
Weak CYP3A inhibition by methadone may reduce lonafarnib metabolism.
What to do
Monitor for lonafarnib adverse effects and for palpitations or syncope, and consider an ECG. Keep lonafarnib at the lowest recommended dose if coadministration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Methadone?
MediHelp rates the interaction as moderate. Lonafarnib and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, and methadone is a weak CYP3A inhibitor that may modestly raise lonafarnib exposure. The effect of lonafarnib on QT is not fully defined, so increased exposure with a QT-prolonging drug is a concern.
How serious is the interaction between Lonafarnib and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lonafarnib adverse effects and for palpitations or syncope, and consider an ECG. Keep lonafarnib at the lowest recommended dose if coadministration is needed.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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