Drug interactions
Lonafarnib + Morphine
Severity: Minor
Lonafarnib and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib weakly inhibits P-glycoprotein and may modestly raise morphine exposure. The clinical significance is uncertain but could include increased sedation or respiratory depression.
What this interaction means in plain words
Lonafarnib and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Morphine belongs to Musculoskeletal.
Why it happens
Weak P-glycoprotein inhibition by lonafarnib may increase morphine absorption and brain penetration.
What to do
Monitor for increased opioid effects when lonafarnib is started. Lower the morphine dose if sedation develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Morphine?
MediHelp rates the interaction as minor. Lonafarnib and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib weakly inhibits P-glycoprotein and may modestly raise morphine exposure. The clinical significance is uncertain but could include increased sedation or respiratory depression.
How serious is the interaction between Lonafarnib and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased opioid effects when lonafarnib is started. Lower the morphine dose if sedation develops.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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