Drug interactions
Lonafarnib + Nilotinib
Severity: Moderate
Lonafarnib and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and nilotinib inhibits CYP3A4, which may increase lonafarnib exposure and its adverse effects. The QT effect of lonafarnib is not well characterized, adding uncertainty alongside nilotinib's QT risk.
What this interaction means in plain words
Lonafarnib and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibition of CYP3A4 reduces lonafarnib clearance.
What to do
Use the lowest lonafarnib dose per labeling, and monitor for gastrointestinal toxicity and for arrhythmia symptoms with ECG as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Nilotinib?
MediHelp rates the interaction as moderate. Lonafarnib and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, and nilotinib inhibits CYP3A4, which may increase lonafarnib exposure and its adverse effects. The QT effect of lonafarnib is not well characterized, adding uncertainty alongside nilotinib's QT risk.
How serious is the interaction between Lonafarnib and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest lonafarnib dose per labeling, and monitor for gastrointestinal toxicity and for arrhythmia symptoms with ECG as indicated.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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