Drug interactions
Lonafarnib + Oxybutynin
Severity: Minor
Lonafarnib and Oxybutynin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin is not a recognized meaningful CYP3A4 inhibitor, so a clinically relevant rise in lonafarnib exposure is unlikely. Lonafarnib is a sensitive CYP3A substrate, but the pairing lacks a credible mechanism.
What this interaction means in plain words
Lonafarnib and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Oxybutynin belongs to Genitourinary.
Why it happens
Oxybutynin is a CYP3A4 substrate with no established inhibitory effect, so no mechanism is confirmed.
What to do
No specific action is needed; monitor for lonafarnib adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Oxybutynin?
MediHelp rates the interaction as minor. Lonafarnib and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxybutynin is not a recognized meaningful CYP3A4 inhibitor, so a clinically relevant rise in lonafarnib exposure is unlikely. Lonafarnib is a sensitive CYP3A substrate, but the pairing lacks a credible mechanism.
How serious is the interaction between Lonafarnib and Oxybutynin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; monitor for lonafarnib adverse effects as usual.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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