Drug interactions
Lonafarnib + Pantoprazole
Severity: Moderate
Lonafarnib and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate and also inhibits CYP2C19, which helps clear pantoprazole. Exposure to either drug may rise, though pantoprazole is only a weak CYP3A inhibitor so the effect on lonafarnib is likely modest. Lonafarnib's effect on QT is not established, so increased exposure is a concern.
What this interaction means in plain words
Lonafarnib and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Possible weak CYP3A inhibition by pantoprazole raising lonafarnib levels, and lonafarnib inhibition of CYP2C19 raising pantoprazole levels.
What to do
If combined, keep lonafarnib at the starting dose and monitor for palpitations, syncope or arrhythmia. Watch for pantoprazole adverse effects and reduce its dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Pantoprazole?
MediHelp rates the interaction as moderate. Lonafarnib and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate and also inhibits CYP2C19, which helps clear pantoprazole. Exposure to either drug may rise, though pantoprazole is only a weak CYP3A inhibitor so the effect on lonafarnib is likely modest. Lonafarnib's effect on QT is not established, so increased exposure is a concern.
How serious is the interaction between Lonafarnib and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If combined, keep lonafarnib at the starting dose and monitor for palpitations, syncope or arrhythmia. Watch for pantoprazole adverse effects and reduce its dose if needed.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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