Drug interactions
Lonafarnib + Paroxetine
Severity: Moderate
Lonafarnib and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, so inhibitors may raise its exposure and toxicities such as GI effects. Paroxetine is not a notable CYP3A inhibitor, so the effect is expected to be small. Lonafarnib also inhibits CYP2D6 in some contexts, which could affect paroxetine.
What this interaction means in plain words
Lonafarnib and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Paroxetine belongs to Central Nervous System.
Why it happens
Possible modest change in CYP3A/CYP2D6 metabolism; the mechanism is not well established for this pair.
What to do
Monitor for lonafarnib adverse effects such as diarrhea, nausea, and fatigue, and for paroxetine adverse effects. Check the ECG if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Paroxetine?
MediHelp rates the interaction as moderate. Lonafarnib and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, so inhibitors may raise its exposure and toxicities such as GI effects. Paroxetine is not a notable CYP3A inhibitor, so the effect is expected to be small. Lonafarnib also inhibits CYP2D6 in some contexts, which could affect paroxetine.
How serious is the interaction between Lonafarnib and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lonafarnib adverse effects such as diarrhea, nausea, and fatigue, and for paroxetine adverse effects. Check the ECG if palpitations or syncope occur.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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