Drug interactions
Lonafarnib + Pazopanib
Severity: Moderate
Lonafarnib and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and pazopanib is a weak CYP3A4 inhibitor that may raise its levels. Lonafarnib can cause gastrointestinal and other toxicity, and its effect on QT is not well defined.
What this interaction means in plain words
Lonafarnib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Pazopanib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by pazopanib reducing lonafarnib metabolism.
What to do
Avoid if possible. If used, keep lonafarnib at the starting dose and monitor for arrhythmia symptoms, gastrointestinal toxicity and liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Pazopanib?
MediHelp rates the interaction as moderate. Lonafarnib and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, and pazopanib is a weak CYP3A4 inhibitor that may raise its levels. Lonafarnib can cause gastrointestinal and other toxicity, and its effect on QT is not well defined.
How serious is the interaction between Lonafarnib and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, keep lonafarnib at the starting dose and monitor for arrhythmia symptoms, gastrointestinal toxicity and liver tests.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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