Drug interactions
Lonafarnib + Prednisolone
Severity: Moderate
Lonafarnib and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and its exposure rises when it is given with CYP3A inhibitors. Prednisolone is not a clinically important CYP3A inhibitor, so any rise in lonafarnib levels is probably small. Higher lonafarnib exposure could increase gastrointestinal toxicity and QT-related arrhythmia risk.
What this interaction means in plain words
Lonafarnib and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Prednisolone belongs to Endocrine.
Why it happens
Possible weak inhibition of CYP3A4-mediated lonafarnib metabolism, which is predicted rather than well established for prednisolone.
What to do
If the combination is needed, continue lonafarnib at the current dose and monitor for palpitations, syncope and ECG changes. Check electrolytes and consider a baseline and follow-up ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Prednisolone?
MediHelp rates the interaction as moderate. Lonafarnib and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a sensitive CYP3A substrate, and its exposure rises when it is given with CYP3A inhibitors. Prednisolone is not a clinically important CYP3A inhibitor, so any rise in lonafarnib levels is probably small. Higher lonafarnib exposure could increase gastrointestinal toxicity and QT-related arrhythmia risk.
How serious is the interaction between Lonafarnib and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is needed, continue lonafarnib at the current dose and monitor for palpitations, syncope and ECG changes. Check electrolytes and consider a baseline and follow-up ECG.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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