Drug interactions
Lonafarnib + Salmeterol
Severity: Major
Lonafarnib and Salmeterol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and can increase salmeterol exposure. Higher levels raise the risk of tachycardia, palpitations, tremor and QT prolongation. Lonafarnib may itself affect cardiac conduction.
What this interaction means in plain words
Lonafarnib and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lonafarnib belongs to Miscellaneous; Salmeterol belongs to Respiratory.
Why it happens
CYP3A4 inhibition by lonafarnib decreases salmeterol metabolism.
What to do
Avoid coadministration where possible and choose a non-CYP3A-dependent bronchodilator. If used together, monitor ECG, heart rate and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Salmeterol?
MediHelp rates the interaction as major. Lonafarnib and Salmeterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a strong CYP3A inhibitor and can increase salmeterol exposure. Higher levels raise the risk of tachycardia, palpitations, tremor and QT prolongation. Lonafarnib may itself affect cardiac conduction.
How serious is the interaction between Lonafarnib and Salmeterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible and choose a non-CYP3A-dependent bronchodilator. If used together, monitor ECG, heart rate and potassium.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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