Drug interactions
Lonafarnib + Selegiline
Severity: Minor
Lonafarnib and Selegiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and any CYP3A inhibition can increase its exposure. Selegiline is at most a weak CYP3A inhibitor, so the effect is likely small, but higher lonafarnib levels raise gastrointestinal and cardiac concerns.
What this interaction means in plain words
Lonafarnib and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Selegiline belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP3A4 by selegiline reducing lonafarnib clearance.
What to do
Monitor for lonafarnib adverse effects such as diarrhea, nausea and QT-related symptoms. Consider reducing the lonafarnib dose if tolerability worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lonafarnib and Selegiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Selegiline?
MediHelp rates the interaction as minor. Lonafarnib and Selegiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate, and any CYP3A inhibition can increase its exposure. Selegiline is at most a weak CYP3A inhibitor, so the effect is likely small, but higher lonafarnib levels raise gastrointestinal and cardiac concerns.
How serious is the interaction between Lonafarnib and Selegiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lonafarnib adverse effects such as diarrhea, nausea and QT-related symptoms. Consider reducing the lonafarnib dose if tolerability worsens.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
