Drug interactions
Lonafarnib + Sofosbuvir-velpatasvir
Severity: Moderate
Lonafarnib and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may raise velpatasvir exposure, though velpatasvir has a wide safety margin. Lonafarnib levels are not expected to be substantially affected by the antivirals.
What this interaction means in plain words
Lonafarnib and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Lonafarnib inhibits CYP3A4, reducing velpatasvir metabolism.
What to do
Monitor for velpatasvir adverse effects such as headache and fatigue. No dose change is established for the antiviral combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Lonafarnib and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor and may raise velpatasvir exposure, though velpatasvir has a wide safety margin. Lonafarnib levels are not expected to be substantially affected by the antivirals.
How serious is the interaction between Lonafarnib and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for velpatasvir adverse effects such as headache and fatigue. No dose change is established for the antiviral combination.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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