Drug interactions
Lonafarnib + Sorafenib
Severity: Moderate
Lonafarnib and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A4 inhibitor and may increase sorafenib exposure. This could worsen sorafenib toxicities such as hand-foot skin reaction, diarrhea and hypertension.
What this interaction means in plain words
Lonafarnib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonafarnib belongs to Miscellaneous; Sorafenib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated sorafenib metabolism by lonafarnib.
What to do
Monitor for sorafenib adverse effects and reduce the sorafenib dose if they occur. Consider an alternative if toxicity persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Sorafenib?
MediHelp rates the interaction as moderate. Lonafarnib and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A4 inhibitor and may increase sorafenib exposure. This could worsen sorafenib toxicities such as hand-foot skin reaction, diarrhea and hypertension.
How serious is the interaction between Lonafarnib and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib adverse effects and reduce the sorafenib dose if they occur. Consider an alternative if toxicity persists.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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