Drug interactions
Lonapegsomatropin + Methylprednisolone
Severity: Moderate
Lonapegsomatropin and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, reducing conversion of cortisone to active cortisol. Patients on glucocorticoid replacement may need higher doses after starting lonapegsomatropin, and the effect of methylprednisolone may be reduced.
What this interaction means in plain words
Lonapegsomatropin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lonapegsomatropin belongs to Endocrine; Methylprednisolone belongs to Endocrine.
Why it happens
Growth hormone inhibits 11-beta-HSD1, lowering local activation of glucocorticoids such as cortisone and prednisone.
What to do
Monitor for signs of adrenal insufficiency in hypoadrenal patients after starting lonapegsomatropin and adjust glucocorticoid dosing. Methylprednisolone is active without 11-beta-HSD1 conversion, so the effect is likely smaller.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Lonapegsomatropin with Methylprednisolone?
MediHelp rates the interaction as moderate. Lonapegsomatropin and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone inhibits 11-beta-hydroxysteroid dehydrogenase type 1, reducing conversion of cortisone to active cortisol. Patients on glucocorticoid replacement may need higher doses after starting lonapegsomatropin, and the effect of methylprednisolone may be reduced.
How serious is the interaction between Lonapegsomatropin and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of adrenal insufficiency in hypoadrenal patients after starting lonapegsomatropin and adjust glucocorticoid dosing. Methylprednisolone is active without 11-beta-HSD1 conversion, so the effect is likely smaller.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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