Drug interactions
Loperamide + Sunitinib
Severity: Moderate
Loperamide and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib is known to prolong the QT interval, and high-dose loperamide can do so too. Together they may raise the risk of torsades de pointes.
What this interaction means in plain words
Loperamide and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loperamide belongs to Gastrointestinal Tract; Sunitinib belongs to Oncology.
Why it happens
Additive QT prolongation; sunitinib may also affect P-glycoprotein.
What to do
Keep loperamide at labeled doses and monitor ECG and electrolytes. Correct potassium and magnesium before use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Loperamide with Sunitinib?
MediHelp rates the interaction as moderate. Loperamide and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib is known to prolong the QT interval, and high-dose loperamide can do so too. Together they may raise the risk of torsades de pointes.
How serious is the interaction between Loperamide and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep loperamide at labeled doses and monitor ECG and electrolytes. Correct potassium and magnesium before use.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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