Drug interactions
Loperamide + Tolvaptan
Severity: Minor
Loperamide and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein and may raise loperamide exposure modestly. Clinical consequences are probably small at standard loperamide doses.
What this interaction means in plain words
Loperamide and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loperamide belongs to Gastrointestinal Tract; Tolvaptan belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein efflux of loperamide.
What to do
Use labeled loperamide doses and watch for excess constipation or sedation. Monitor fluid status and sodium if diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loperamide
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Loperamide with Tolvaptan?
MediHelp rates the interaction as minor. Loperamide and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein and may raise loperamide exposure modestly. Clinical consequences are probably small at standard loperamide doses.
How serious is the interaction between Loperamide and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use labeled loperamide doses and watch for excess constipation or sedation. Monitor fluid status and sodium if diarrhea occurs.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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